Real World Evidence

Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C)
Objective: To evaluate whether synthetic data derived from a national coronavirus disease 2019 (COVID-19) dataset could be used for …
Jason A. Thomas, Randi E. Foraker, Noa Zamstein, Jon D. Morrow, Philip R.O. Payne, Adam B. Wilcox, the N3C Consortium
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Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C)
The National COVID Cohort Collaborative: Analyses of Original and Computationally Derived Electronic Health Record Data
Background: Computationally derived (“synthetic”) data can enable the creation and analysis of clinical, laboratory, and diagnostic …
Randi E. Foraker, Aixia Guo, Jason A. Thomas, Noa Zamstein, Philip R.O. Payne, Adam B. Wilcox, the N3C Consortium
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Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States
Early identification of symptoms and comorbidities most predictive of COVID-19 is critical to identify infection, guide policies to …
Asieh Golozar, Lana YH Lai, Anthony G Sena, David Vizcaya, Lisa M Schilling, Vojtech Huser, Fredrik Nyberg, Scott L Duvall, Daniel R Morales, Thamir M Alshammari, Hamed Abedtash, WaheedUlRahman Ahmed, Osaid Alser, Heba Alghoul, Ying Zhang, Mengchun Gong, Yin Guan, Carlos Areia, Jitendra Jonnagaddala, Karishma Shah, Jennifer CE Lane, Albert PratsUribe, Jose D Posada, Nigam H Shah, Vignesh Subbian, Lin Zhang, Maria Tereza Fernandes Abrahão, Peter R Rijnbeek, Seng Chan You, Paula Casajust, Elena Roel, Martina Recalde, Sergio FernándezBertolín, Alan Andryc, Jason A. Thomas, Adam B Wilcox, Stephen Fortin, Clair Blacketer, Frank DeFalco, Karthik Natarajan, Thomas Falconer, Matthew Spotnitz, Anna Ostropolets, George Hripcsak, Marc Suchard, Kristine E Lynch, Michael E Matheny, Andrew Williams, Christian Reich, Talita DuarteSalles, Kristin Kostka, Patrick B Ryan, Daniel PrietoAlhambra
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The National COVID Cohort Collaborative (N3C): Rationale, Design, Infrastructure, and Deployment
Objective: COVID-19 poses societal challenges that require expeditious data and knowledge sharing. Though organizational clinical data …
Melissa A Haendel, Christopher G Chute, Tellen D Bennett, David A Eichmann, Justin Guinney, Warren A Kibbe, Philip R O Payne, Emily R Pfaff, Peter N Robinson, Joel H Saltz, Heidi Spratt, Christine Suver, John Wilbanks, Adam B Wilcox, Andrew E Williams, Chunlei Wu, Clair Blacketer, Robert L Bradford, James J Cimino, Marshall Clark, Evan W Colmenares, Patricia A Francis, Davera Gabriel, Alexis Graves, Raju Hemadri, Stephanie S Hong, George Hripscak, Dazhi Jiao, Jeffrey G Klann, Kristin Kostka, Adam M Lee, Harold P Lehmann, Lora Lingrey, Robert T Miller, Michele Morris, Shawn N Murphy, Karthik Natarajan, Matvey B Palchuk, Usman Sheikh, Harold Solbrig, Shyam Visweswaran, Anita Walden, Kellie M Walters, Griffin M Weber, Xiaohan Tanner Zhang, Richard L Zhu, Benjamin Amor, Andrew T Girvin, Amin Manna, Nabeel Qureshi, Michael G Kurilla, Sam G Michael, Lili M Portilla, Joni L Rutter, Christopher P Austin, Ken R Gersing, the N3C Consortium, Jason A. Thomas
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Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS
Background:: Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic …
Daniel Prieto-Alhambra, Kristin Kostka, Talita Duarte-Salles, Albert Prats-Uribe, Anthony Sena, Andrea Pistillo, Sara Khalid, Lana Lai, Asieh Golozar, Thamir M Alshammari, Dalia Dawoud, Fredrik Nyberg, Adam Wilcox, Alan Andryc, Andrew Williams, Anna Ostropolets, Carlos Areia, Chi Young Jung, Christopher Harle, Christian Reich, Clair Blacketer, Daniel Morales, David A Dorr, Edward Burn, Elena Roel, Eng Hooi Tan, Evan Minty, Frank DeFalco, Gabriel de Maeztu, Gigi Lipori, Heba Alghoul, Hong Zhu, Jason A. Thomas, Jiang Bian, Jimyung Park, Jordi Martínez Roldán, Jose Posada, Juan M Banda, Juan P Horcajada, Julianna Kohler, Karishma Shah, Karthik Natarajan, Kristine Lynch, Li Liu, Lisa Schilling, Martina Recalde, Matthew Spotnitz, Mengchun Gong, Michael Matheny, Neus Valveny, Nicole Weiskopf, Nigam Shah, Osaid Alser, Paula Casajust, Rae Woong Park, Robert Schuff, Sarah Seager, Scott DuVall, Seng Chan You, Seokyoung Song, Sergio Fernández-Bertolín, Stephen Fortin, Tanja Magoc, Thomas Falconer, Vignesh Subbian, Vojtech Huser, Waheed-Ul-Rahman Ahmed, William Carter, Yin Guan, Yankuic Galvan, Xing He, Peter Rijnbeek, George Hripcsak, Patrick Ryan, Marc Suchard
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Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS
Assessing the Utility of Language and Voice Biomarkers to Predict Cognitive Impairment in the Framingham Heart Study Cognitive Aging Cohort Data
Background: There is a need for fast, accessible, low-cost, and accurate diagnostic methods for early detection of cognitive decline. …
Jason A. Thomas, Hannah A. Burkhardt, Safina Chaudhry, Anthony Ngo, Saransh Sharma, Larry Zhang, Rhoda Au, Reza Hosseini Ghomi
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Assessing the Utility of Language and Voice Biomarkers to Predict Cognitive Impairment in the Framingham Heart Study Cognitive Aging Cohort Data
Screening Entire Healthcare System ECG Database: Association of Deep Terminal Negativity of P wave in lead V1 and ECG Referral with Mortality
Background: Each encounter of asymptomatic individuals with the healthcare system presents an opportunity for improvement of …
Allison Junell, Jason A. Thomas, Lauren Hawkins, Jiri Sklenar, Trevor Feldman, Charles A Henrikson, Larisa G Tereshchenko
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Screening Entire Healthcare System ECG Database: Association of Deep Terminal Negativity of P wave in lead V1 and ECG Referral with Mortality